Pigments pathology ppt Pigment accumulations include lipofuscin, melanin, hemosiderin, and exogenous pigments like carbon. Ready access to a sink with hot and cold water. Jan 12, 2020 · Unformatted text preview: Cellular Pathology Lecture #17 Histochemistry: Pigments & Minerals Ephraim Imhotep Zulu, BScBMS, MScPath University of Zambia School of Medicine Department of Biomedical SciencesPigments • Are coloring agents deposited, frequently as cytoplasmic inclusions or granules in cells and tissue. A biological pigment is any coloured material of plant or animal cell. Haemoglobinuria ( excretion TYPES OF PIGMENTS. It is made up of Iron and Protein It’s molecular weight is 68000. Perl’s prussian blue reaction – for The pigment is intracellular. Biliverdin is excreted in birds and amphibia while in mammals it is further degraded Oct 19, 2024 · 7. 3 April - 9 April. There are two main types: dystrophic calcification occurs in dead or damaged tissue with normal calcium levels, while metastatic calcification affects normal tissues and results from disorders that increase calcium levels in the blood (hypercalcemia). Objectives. 10 April - 16 April. Non-haematogenous – melanin, lipofuschin Sep 17, 2017 · 4. 17 April - 23 April. Dermal connective tissue - systemic sclerosis Panniculus / Sub cut tissue : erythema nodosum, Neoplasms – fibroma, lipoma, sarcoma . A passionate National level Oct 16, 2015 · 14. Inflammatory Neoplastic Degeneration. • Normal haemoglobin content of blood is about 13-14g/100ml for males and 11-12g/100ml for females. Hemosiderin contains stored iron and appears as yellow-brown granules. Solar lentigines Also referred to as liver spots or sun spots. The Hematoxylin and Eosin stain (H&E) is the most widely used histological stain because : comparative simplicity Ability to demonstrate clearly an enormous number of different tissue structures. Lipofuscin Lipofuscin is the name given to finely granular yellow-brown pigment granules composed of lipid-containing residues of lysosomal digestion. • Systemic (organ and organ system) pathology examines the specific responses of specialized organs and tissues to more or less well- defined stimuli. Histopathology- • a. Cell injury - Reversible vs Irreversible May 17, 2024 · Brown-black pigment formed by melanocytes Melanocytes Mammalian pigment cells that produce melanins, pigments found mainly in the epidermis, but also in the eyes and the hair, by a process called melanogenesis. Jul 24, 2014 · Lecturer name: Dr. pdf format. Autogenous Pigments-color substances formed in the organism as metabolism products • melanin • ceroid • lipofuscin Jan 2, 2025 · Understand the classification and effects of exogenous pigments like traumatogenic and gastrointestinal substances, and pneumoconioses caused by inhaled dust particles. Prague Oct 14, 2022 · PDF | A training course entitled (introducing some specialized Histologic and embryonic technologies in zoology) for the period of 10-10-13-2022, November | Find, read and cite all the research Introduction cell injury pathology lecture. 19k views • 50 slides Aug 30, 2010 · Pigment disorders: hyper, hypo, Dermis: Blood vessels - urticaria, contact dermatitis. These accumulations can be transient or permanent and range from harmless to toxic. ” Jul 27, 2018 · 2. Endogenous pigments. eg- Butterfly’s wings. Basic Principles of Cellular and Organ Pathology Exogenous Pigments Jaroslava Dušková Inst. Pigments Classification: • endogenous • autogenous • hemoproteins derived • exogenous. USES • Traditionally used for demonstration of muscle striations, glial cells and fibrin. Mechanisms of accumulation. pink by oxyhaemoglobin in the blood within the dermis. S. Other causes discussed include drug-induced melanosis, smoker's melanosis, melasma, and systemic diseases. Nov 13, 2017 · 7. Then wash with water. It is a conjugated protein, & Chromoprotein. Specific diseases associated with accumulations of these substances are provided as examples. Immunology • 5. 40 year old woman with colonic lymphoid hyperplasia in melanosis coli (Arch Pathol Lab Med 2001;125:1110) General Veterinary Pathology. Associate Professor of Pathology School of Health Sciences. Medical Genetics • 8. Increase osmotic pressure. Related Posts. Pigmentation in organisms serves biological purposes- • Mimicry • Aposematism (warning) • Protection from sunburn etc. Exogenous pigments • Pigments or minerals that are formed externally and taken into the body eg coal dust, copper 3. Mechanisms Of Cell Death Physiological, as in cell life cycle Necrosis: Morphologic changes seen in dead cells within living tissue Autolysis: Dissolution of dead cells by the cells own digestive enzymes Apoptosis: Programmed cell death “Apoptosis is a pathway of cell death that is induced by a tightly-regulated suicide program in which cells destined to die activate enzymes that degrade Mar 2, 2017 · 47. They absorb visible light within a narrow band between 400-800 nm. etc. 2021 Staining V – pigments and minerals – L8 Describe classification of pigments found in tissue sections, describe the pathological conditions that are associated with these types of pigments and their demonstration techniques and list the main minerals found in tissue sections and describe how they can be identified. Intracellular Inclusions. Proper classification, identification, and demonstration of common pigments and minerals encountered in the histology laboratory are necessary to achieve the correct diagnosis and to assure the highest quality patient care. formalin 2. Normal skin colour The colour of normal skin comes from a mixture of pigments 1. Nov 3, 2017 · Subspecialties in Pathology • 1. The examples of injected pigments are prolonged use of ointments containing mercury, dirt left accidentally in a wound Artefact pigments • Usually as a result of fixation eg formalin pigment 2. • MANIFESTS as multiple round or oval purple macular papular lesions that are dilated capillaries just underneath epithelium, measuring less than 0. 5. vs. Faculty, Charles Univ. . Large room, well illuminated and properly ventilated. 3 Introduction. Feb 12, 2019 · This document discusses various special stains used in pathology and their principles and results. • Reduced uptake in liver, impaired conjugation • Lack of enzymes • Impaired intrahepatic secretion due to hepatic damage, intrahepatic cholestasis • Impaired extrahepatic secretion due to obstruction - Due to bile duct obstruction. H&E stain is routine stain. These spots are caused by UV sun exposure and the degree depends on how much UV light these melanin pigments are exposed to. HIDING POWER Hiding Power is the ability of paint to completely obliterate any underlying color and usually expressed as the number of square meters of a surface covered by one liter of paint. 27 March - 2 April. • However, melanocytes are enlarged and have increased numbers of dendrites. Type II Hypersensitivity. Pigments Definition: colored substances in the organism or environment. In a town like Balasore, where healthcare services are expanding to meet the growing needs of its population, access to reliable pathology labs is crucial. • General pathology is concerned with the basic reactions of cells and tissues to abnormal stimuli that underlie all diseases. schistosome 72. Specificity of the Reaction: The method should be Feb 11, 2009 · Vitamin A Functions Deficiency Maintains normal vision Reduced light Vitamin A (retinol) -containing pigments rhodopsin (rod cells) and iodopsins (cone cells) Maintains ocular epithelium (lubrication, corneal) Impaired vision (early manifestation) Night blindness Xerophthalmia (dry), keratin build-up (Bitot spots), keratomalacia, and eventual Oct 12, 2015 · The normal color represents the combined effect of a number of factors: • The concentration and state of dilation of capillaries in the underlying connective tissue, • The thickness of the epithelium, • The degree of keratinization, • And the amount of melanin pigment in the epithelium. It is actually a composite of compounds known as flavones, flavonols and flavanones. VITILIGO • Local loss of pigment may occur around nevi and melanomas, the so-called halo phenomenon • Vitiligo-like leukoderma occurs in 1% of melanoma patients • In those previously dx with melanoma, it suggests metastatic disease • Paradoxically, patients who develop leukoderma have a better prognosis than patients without it • Halo nevi are more common in patients with Mar 7, 2016 · Pigments - Download as a PDF or view online for free. Molecular Pathology. Also, a solution of 70% alcohol containing 3 mL of ammonium hydroxide for 30 minutes to 3 hours. a. Overview. Ultimately both Epidermis & Dermis involved * Mar 10, 2023 · 14. This pigment cannot be removed by lysosomal degradation or exocytosis. These must be monitored as they may develop into skin Feb 1, 2021 · Deposition of dark melanin-like pigment in colonic macrophages. 13 March - 19 March. ACINIACINI 1 2 3 Portal tract Central vein Portal tract Traditional conception of liver histology, arbitrarily divided into centrilobular, periportal (peripheral) & midlobular zones Acini are defined by micro- circulatory layout of liver, with a central axis (portal tract & its afferent vessels), surrounded A variety of pigments and minerals occur in the body naturally or when pathologic conditions present. Pathol. ” Common in heart muscle called “brown atrophy. Decreased ATP production Increased mitochondrial permeability Leakage of Ca++ Ca-activated hydrolases degrade lipid, protein, RNA, DNA Denatured nucleic acid and protein may be large or small After initial “blebbing” of ER or plasma membranes, membranes burst The pigment is intracellular. PRESERVATION OF URINE SAMPLE Refrigeration (4-6°C) is the best general method of preservation of urine sample up to 8 hours. Exogenous pigmentation is commonly due to foreign-body implantation in the oral mucosa. Causes • Overproduction of bilirubin due to increased haemolysis. Formalin and glutaraldehyde fixation are discussed in depth. Jul 24, 2012 · General Pathology (PATH 303) Lecture # 6 INTRACELLULAR ACCUMULATIONS. non- hematogenous EXOGENOUS PIGMENTS 1. 2. Cytopathology • 2. Hematogenous pigments: Hemosiderin, Haemoglobin, Bile pigments. It is seen in the myocardial fibres, hepatocytes, Leydig cells of the testes and in neurons in senile dementia. PODCAST. Mar 11, 2019 · 5. Feb 1, 2014 · Retinal atrophy causes constriction of retinal vessels, optic nerve head atrophy and accumulation of retinal pigment around blood vessels Microscopic (histologic) description Migration of macrophages and retinal pigment epithelial cells with melanin into retina, particularly around vessels Sep 9, 2023 · 6. Hiding power Oct 3, 2017 · Injected Pigments (Tattooing) Pigments like India ink, cinnabar and carbon are introduced into the dermis in the process of tattooing where the pigment is taken up by macrophages and lies permanently in the connective tissue. Pseudomelanosis Appearance of grey, green, or black pigment in the tissues after death Hydrogen sulphide produced during putrefaction combines with the iron to form iron sulphide, a black pigment Its concentration and combination with other tissue pigments result in a variety of shades of green, grey and black 8. 4 million RBCs/μL Adult female = 4. Periodic Acid Schiff (PAS) stain Reagents: Preparation of staining solutions 1) Periodic Acid Solution : Periodic Acid : 1 gram Distilled water : 100 ml 2) Schiff’s Reagent : Fuchsin Basic : 1 gm Distilled water : 100 ml Sodium metabisulphite : 2 gm Conc. General Pathology (PATH 303) Lecture # 6 INTRACELLULAR ACCUMULATIONS. Oct 3, 2017 · 3. Metaplasia: Reversible change in which one adult cell type ( epithelial or mesenchymal) is replaced by another adult cell type. , M. Intracellular Accumulations and Pigments. Extracellular changes • The changes occuring in the intercellular spaces and in the lumen of blood vascular system are examples Dementia • Dementia is a Feb 3, 2015 · The phosphotungstic acid binds all the available hematein to form blue lake pigment. Read And Learn More: General Pathology Feb 24, 2020 · 52. Hemoglobin AbnormalitiesHemoglobin Abnormalities There are 3 main categories of inheritedThere are 3 main categories of inherited Hemoglobin abnormalities:Hemoglobin abnormalities: – Structural or qualitative: The amino acid sequenceThe amino acid sequence is altered because of incorrect DNA codeis altered because of incorrect DNA code (Hemoglobinopathy). Dec 10, 2020 · Bile pigment (yellow / green / brown) visible histologically within hepatic parenchyma, usually perivenular May be present within hepatocyte cytoplasm, hepatocyte canaliculi, ductule lumens or large duct lumens Jul 4, 2012 · Human Cancer Site for Agents or Groups of Which Reasonable Agents Evidence Is Available Typical Use or Occurrence Arsenic and arsenic Lung, skin, Byproduct of metal smelting; component of alloys, compounds hemangiosarcoma electrical and semiconductor devices, medications and herbicides, fungicides, and animal dips Asbestos Lung, mesothelioma Cellular Pathology Intracellular Accumulations and Pigments 2nd Year Pathology 2010 2 Overview In this lecture you will learn about: The types and significance of intracellular inclusions. Intracellular deposits of fat create bands of yellow myocardium, alternating with bands of darker, red- brown, uninvolved myocardium. Imbibition of bile Yellowish Mar 8, 2018 · 5. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called melanosomes. Mar 2, 2019 · • Shortening of Telomeres • Accumulation of aging pigments- Lipofuscin accumulation • Accumulation of free radicals • Weakened immune system • Decrease in rate of cell division 8. -> jaundice. Rapid destruction by reticuloendothelial system. Jan 28, 2015 · 2. ENDOGENOUS PIGMENTS Pigments that are formed inside the body and may accumulate in tissues Eg: Lipofuscin, hemosiderin, and certain derivatives of hemoglobin such as melanin, bilirubin LIPOFUSCIN Also known as lipochrome or wear-and-tear pigment Endogenous pigments composed of Apr 18, 2017 · 20. Sep 20, 2000 · pathology labs in balasore (1) - Pathology labs play a vital role in modern healthcare, acting as the cornerstone for accurate diagnosis and effective treatment. (10%) 3. • Head and neck pathology Foundations in diagnostic pathology (2nd edition). Dec 21, 2014 · Pigments can be exogenous or endogenous. Apr 28, 2018 · 11. Dec 26, 2012 · General Pathology (PATH 303) Lecture # 6 INTRACELLULAR ACCUMULATIONS. Large formalin container, photographic facilities. General. com - id: 7666c8-Yzg4Z Pneumoconiosis is a general term applied for any permanent deposition of substantial amounts of particulate matter in lung disease by inhalation; Depending upon the type of exogenous pigment, the conditions are termed as follows Jun 5, 2020 · Liver pathology & Disease condition - Download as a PDF or view online for free. Endogenous pigments • Pigments that are formed within the body i. (Hemoglobinopathy). Feb 14, 2016 · HAEMOGLOBIN It is a Red pigment Present in RBC of Blood. lead 4. Presentation on theme: "Exogenous Pigments General Pathology"— Presentation transcript: 1 Exogenous Pigments General Pathology Basic Principles of Cellular and Organ Pathology Exogenous Pigments Jaroslava Dušková Inst. yellow from carotene mainly in subcutaneous fat and in the horny layer of the epidermis. Presentation of Normal Chemical Composition: The procedure must not block or denature the reactive chemical groups being analyzed, or change normally non reactive groups into reactive groups. Exogenous pigments 2. Structural colour – result of selective reflection. Surgical pathology • B. The pigments used must prevent light from passing through the film to the previous colored layer and back to the eye of an observer. Adaptive response Hyperplasia: An increase in number of cells in an organ or tissue resulting in enlargement of the organ or tissue. Endogenous pigments include melanin, hemoglobin, hemosiderin and carotene. 4 Jun 13, 2023 · Pigments Pigments are coloured substances present in most living beings including humans and may be of two broad categories: endogenous and exogenous Endogenous Pigments: Endogenous pigments are either normal constituents of cells or accumulate under special circumstances for example, Melanin, alkaptonuria, haemoprotein-derived pigments, and lipofuscin. Prague – A free PowerPoint PPT presentation (displayed as an HTML5 slide show) on PowerShow. Pigment colour is same for all viewing angles. • Mild pigment incontinence is sometimes present, along with a perivascular lymphohistiocytic infiltrate and increased vascularity. Endogenous pigments- produced either within tissues and serve a physiological function, or are by products of normal metabolic processes. Prague Nov 7, 2019 · SPECIAL STAINS. The pigment is a complex of lipid and protein derived from oxidation of polyunsaturated lipids derived from free radical injury and lipid peroxidation. • Wheater`s functional histology(6th edition). silica 3. g. Diagnosis, clinical features, pathology, and treatment are described for different conditions presenting as oral pigmentation. Quiz. It describes endogenous pigments such as hematogenous pigments (hemosiderin, hemoglobin), bile pigments, porphyrins, melanin, lipofuscin and chromaffin. Lipofuscin (Wear and Tear Pigment) Lipofuscin or lipochrome is yellowish-brown intracellular lipid pigment (lipo = fat, fuscus = brown). Discuss the prevention and/or removal of artifact pigments. B. Megaloblastic anemia -1 ppt; Pernicious anemia ppt; Hemolytic anemia. Experimental pathology • 6. asbestos 2. This blog will be helpful for Medical, Dental and Paramedical students in understanding various topics which are prepared by the topmost Doctors in the medical field. Maha Arafah Lecture Date : -9-2012. There is no natural blue pigment Hair colour is determined by the relative amounts of the different types of melanin. However, the pigment may, at times May 20, 2016 · Proteins can accumulate intracellularly in conditions like myeloma or nephrotic syndrome. A regressive change in the adult cells manifested by variation in their size, shape & orientation. Most of them are in . IC accumulations of pigments • Melanin; is a brownish-black pigment produced by the melanocytes found in the skin. Read Basic Principles of Cellular and Organ Pathology Autogenous Pigments Jaroslava Dušková Inst. It also discusses mucin stains like PAS, mucicarmine and Alcian blue; melanin, lipochrome, iron, fat, AFB, fungal and connective tissue stains. Exogenous pigments come from outside sources like carbon, air pollution, or tattoos. It is the preliminary or the first stain applied to the tissue sections Gives diagnostic information in most cases. brown of melanin 3. Title: General Pathology 1 General Pathology . Classification ppt; Hereditary spherocytosis and G-6-PD deficiency PNH and G6PD deficiency hemolytic anemia; Sickle cell anemia; THALASSEMIA; Aplastic anemia, Myelophthisic anemia Jun 7, 2021 · Anthoxanthins Anthoxanthin is a pigment and is similar to anthocyanin, but it exists in less oxidized state as the oxygen on the central group is uncharged. 1. Steatosis (fatty change, lipidosis); it is abnormal accumulation of neutral fats (triglycerides) within parenchymal cells. Prague Pigments Definition: colored substances in the organism or environment Pigments Classification: endogenous hemoproteins derived autogenous exogenous Exogenous Pigments - colored substances entering the organism via traumatic lesions gastrointestinal Sep 20, 2019 · 13. Large table with Features such as hyperpigmentation of the basal cell layer, pigment incontinence within the dermis and accumulation of pigment laden macrophages around blood vessels and eccrine glands often seen (eMedicine: Drug-Induced Pigmentation Workup [Accessed 20 November 2022]) Postinflammatory hyperpigmentation: Jul 11, 2015 · 3. Such structure include the amount and quality of wax and Feb 1, 2014 · - 23 - ENDOGENOUS PIGMENTS 1. Eosin stains cell cytoplasm and most connective tissue fibers in varying shades and intensities of pink, orange, and red. Prague Feb 2, 2017 · Exogenous pigmentation includes amalgam tattoos. Define terminology associated with pigments and minerals. HISTOLOGY OFHISTOLOGY OF THETHE LIVERLIVER • HEPATICHEPATIC LOBULESLOBULES vs. Pigments may be endogenous in origin or exogenously introduced in the body. Feb 20, 2021 · References: • Rosai & Ackerman Surgical pathology (1st south asian edition). Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. Hemosiderin Breakdown product of haemoglobin composed of ferric iron and protein Seen as yellow-brown granules 3 methods for demonstration : 1. 3 gm Procedure: 1) Fix films for 15 min. Some structural defense are present in the plant even before the pathogen comes in contact with the plant. Slideshow 2299090 by ziazan Apr 7, 2014 · hematogenous 2. 1 May - 7 May. Increase viscosity. They are referred to as residual bodies representing indigestible residues of autophagic vacuoles. 3 intracellular accumulations of fats,proteins,carbohydrates,pigments dr ira bharadwaj mci teacher id: pat 2300569 kuhs faculty id: m21512 Sep 2, 2017 · This document discusses tissue fixation in pathology. To correlate the clinical features with the structural and functional pathological alterations in the organs due to the disease process. Aug 6, 2020 · 1. IMPORTANCE OF THE STUDY OF PATHOLOGY FOR NURSES 5. Leukoderma:- There is local loss of the pigment. b. carbon ARTIFACT PIGMENTS 1. They may occur anywhere on the body and vary in colour from light brown to black. Classify pigments and minerals. 20 March - 26 March. Exogenous pigments 1. (Foundation Block, Pathology). 7. Owner and Founder of "DPMA" (Devesh Premier Medical Academy), and DEVAANSH publication. • Robbins & cotran pathologic basis of disease (8thedition). Aug 1, 2014 · Cellular Pathology. Shelves for specimen container. Shashidhar. Jan 26, 2014 · The document then discusses the processes and sites of accumulations, including accumulation of lipids (resulting in steatosis), cholesterol, proteins, glycogen, and pigments. Chart and Diagram Slides for PowerPoint - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. 6. Pre formed or pre existing defense structures The first line of defense of a plant against pathogens is its surface,which the pathogen must adhere to and penetrate if it is to cause infection. 1-Lipofuscin (lipochrom pigment), is a yellow brown, intracytoplasmic pigment, which is seen in the cells undergoing slow atrophy. 24 April - 30 April. Biliary Cirrhosis (5-10%) 4. In this lecture you will learn about: The types and significance of intracellular inclusions. Ready access to formalin Box of instruments, Box with cassettes, labels. Normal cellular constituents in excess: Water Fat Protein Dec 8, 2014 · The products of heme oxygenase reaction are biliverdin (a green pigment), Fe3+ & carbon monoxide (CO). It is considered to be one of the aging or "wear-and-tear" pigments, found in the liver, kidney, heart muscle, retina, adrenals, nerve cells, and ganglion cells. Jul 21, 2024 · 6. May 22, 2021 · This document defines pathology and outlines the key steps and tools involved in pathological examination. pa 2. Haematology • 3. 6 March - 12 March. Hematoxylin stains cell nuclei blue black shows good intranuclear detail. Read less Aug 14, 2014 · Pigments and accumulations. Cutting board placed inside a metal box designed in such a fashion that all the fluids flow directly into the sink. Dr huzlinda hussin Dept of pathology 13 march 2018. in methanol. 8 million RBCs/μL Life span 120 days Nov 14, 2019 · 6. mercury 4. To appraise the evolution of disease from its causes to the clinical presentation including signs and symptoms of diseases. Oral pigmentation may be exogenous or endogenous in origin. Most common endogenous pigment is melanin. Classified as: 1. Pigment cirrhosis in haemochromatosis (5%) 5 May 7, 2012 · Oculocutaneous Albinism Decreased VA~20/100 or less Nystagmus, photophobia, no fundus pigment, light irides that transilluminate, lack foveal reflex, absence of pigment in skin and hair Ocular Albinism X-linked recessive-affects males, nystagmus, photophobia, reduced VA(20/70-20/200), absence of retinal pigment, iris transillumination, normal Jul 8, 2012 · Endogenous Accumulations • Lipofuchsin- a yellowish brown pigment having a high lipid content, often found in atrophied cells of old age. • Bilirubin; is a yellowish pigment, mainly produced during the degradation of hemoglobin. The rest of phosphotungstic acid stains the red-brown components, such as collagen. It describes hematoxylin and eosin staining which stains cell nuclei purple and cytoplasm pink. Geographic pathology • 7. INTRACELLULAR ACCUMULATIONS and CALCIFICATION . Jan 8, 2025 · Tattoo (black splotches of pigment in the dermis) [Lecturer's PPT] B. It is commonly observed in areas where there have been collar, saddle, or harness injuries. They can be organic or inorganic compounds that remain Sep 1, 2014 · 54. • Hemosiderin; is an iron-containing pigment derived from ferritin. Oct 16, 2016 · 2. INTRODUCTION PIGMENTS are colored substances, some of which are normal constituents of cell, whereas others are abnormal and accumulate in cells only under special circumstances. Discuss methods of special stains procedures for demonstrating: iron, asbestos, calcium, melanin, bile, copper, aluminum, and urates. The Goal of Histochemistry Presentation of Normal Chemical Distribution: The substance being analyzed must not diffuse away from its original site. malaria 3. Pathology is the study of disease through investigation of causes, mechanisms, and tissue changes. Anthoxanthins are white, pale yellowish, water soluble pigments found in a plant’s cell sap. May 29, 2021 · Injected Pigments (Tattooing) Pigments are introduced into the dermis in the process of tattooing where the pigment is taken up by macrophages sand lies permanently in the connective tissue 21. Basic Principles of Cellular and Organ Pathology ; Exogenous Pigments ; Jaroslava Dušková Inst. Carbon – in anthracosis; Tattooing; Endogenous pigments. To understand the morphological changes, which take place in the body during Basic Principles of Cellular and Organ Pathology Blood Derived Pigments Jaroslava Du kov Inst. Heme promotes the activity of this enzyme. ppt format and . Participants. Thus pigments greatly differ in origin, chemical constitution, and biological significance. Learning objective. May 20, 2016 · INTRACELLULAR ACCUMULATIONS: PIGMENTS [/su_youtube] Share: Rate: Loves to promote social media for education in Pathology. e. Chemical pathology • 4. Toluene: It forms a thin layer over the surface Dr Devesh Mishra, M. Pathology. It begins by describing the overall tissue processing steps and importance of fixation. ,1st Med. It represents residue of oxidized lipid derived from digested membrane of organelles 1-Particularly prominent in the cells of the liver & heart of the elderly (brown atrophy of the heart). Glycogen storage diseases result in glycogen accumulation in cells. com - id: 47a599-OTYyY Feb 7, 2021 · PIGMENTS • Pigments are the substances occurring in living matter which absorb visible light and impart specific colour. Lipofuscin; Melanin; Hemosiderin; Bilirubin; Reference Vinay kumar Oct 3, 2017 · Pathological calcification involves the abnormal deposition of calcium salts in tissues other than bone. Demonstration of hemosiderin • Hemosiderin is distinguished from other yellow pigments by Purls Prussian blue reaction. Disadvantages if haemoglobin present in plasma. Aug 24, 2018 · Red blood cells Shape Circular biconcave non-nucleated Size Diameter = 7 – 8 μm Thickness = 2. Bone marrow ppt; Hematopoiesis & BoneMarrow ppt; Iron deficiency anemia; Megaloblastic anemia. The main sources are tissues and organs, and sometimes whole bodies. More severe than hydropic degeneration. Structural defence mechanisms A. Basic Principles of Cellular and Organ Pathology Blood Derived Pigments Jaroslava Du kov Inst. Understand the pathological changes leading to abnormal accumulations of pigments and other substances in cells. D. Oct 7, 2017 · This blog contains a compilation of lecture notes of various medical subjects. • In un fixed tissue hemosiderin is insoluble in alkaline but freely soluble in strong acid solutions after fixation in formalin, it slowly soluble in dilute acids • Fixatives that contain acids can remove hemosiderin or alter it in such a way that the reaction are Jul 4, 2023 · • Melanin pigment is located in a “cap” overlying the keratinocyte nuclei. The color of oral pigmentation can vary depending on the quantity and depth or location of the pigment. They are inhaled and transported to lymph nodes by macrophages, causing black coloring of the lungs and lymph nodes. Following chemical preservatives can be added to the 24-hour urine sample: Hydrochloric acid: It is used for preservation of a 24- hour urine sample for adrenaline, noradrenaline, vanillylmandelic acid, and steroids. 5 cm in diameter • more than100 purple papules on the vermilion and mucosal surfaces of the lips as well as on the tongue and buccal mucosa, the facial skin and neck are also involved • Microscopically numerous dilated vascular channels Mar 2, 2014 · Pathology of uvea - Download as a PDF or view online for free Pathology of uvea • Download as PPT, PDF 1-Anterior border layer 4-Anterior pigment epithelium Aug 24, 2014 · Removal of fixation pigmentsRemoval of fixation pigments Formalin Pigments Immerse the sections in saturated absolute alcohol with picric acid for 10 mins to 3 hrs. 8 May - 14 May Jan 18, 2019 · 12. nevus, or malignant melanoma. It classifies pigments as endogenous (produced within tissues) or exogenous (deposited from outside). Haematogenous – haemosiderin, bile ii. • Normal melanocyte numbers in all cases. • David J Dabbs Diagnostic immunohistochemistry (3rd edition). 5 μm Colour Red (haemoglobin pigment) Count Adult male = 5. Learn about conditions like silicosis, asbestosis, and coal workers’ disease, their stages, pathogenesis, complications, and Jan 3, 2018 · 2. ppt - Download as a PDF or view online for free ( 3 3 ) ) Pigmentation Pigmentation -: -: Endogenous or exogenous Basic Principles of Cellular and Organ Pathology Exogenous Pigments Jaroslava Dušková Inst. Exogenous pigments. Definition of Terms • Pathology: study of diseases and mechanisms that produce disease • Etiology: study of causes of diseases • Pathogenesis: underlying mechanisms that produce disease • Pathophysiology: the functional changes associated with or resulting from disease or injury • Morphology: gross or microscopic appearance of (tissues) NB: General pathology focuses on the May 2, 2020 · • Erythrocytes contain the pigment haemoglobin, which imparts the red colour to blood, and carries oxygen from lungs to various parts and carbon dioxide from the tissues. Prague Pigments Definition: colored substances in the organism or environment Pigments Classification: endogenous autogenous hemoproteins derived exogenous Autogenous Pigments - color substances formed in the organism as metabolism products melanin ceroid Jan 21, 2015 · Branches of pathology • General Pathology • Systemic pathology. Apr 20, 2018 · This document discusses different types of pigments found in tissues. Title: Pathology of Degenerations 1 The secret to success is to start from scratch and keep on scratching! Dennis Green 2 Pathology of Degeneration Ageing Dr. HCl : 2 ml Charcoal activated : 0. Forensic pathology & autopsy work • C. This lake stains muscle cross striations, fibrin, nuclei, and other tissue elements blue. Mar 4, 2018 · This document discusses various endogenous pigments found in tissues and their diagnostic applications. Also called the “wear-and-tear pigment. Venkatesh M. The pigment is often found in atrophied cells of old age and hence the name ‘wear and tear pigment’. The main types of fixatives are then outlined, including coagulant, cross-linking, and compound fixatives. People with lighter skin tone are said to be more prone to sunspots. hmgpohbynkxxsfgzgydfkkafgbpohfbkbhenmllrbzkrghpn