4 types of dengue The 2009 revised dengue case classification 6. Through mosquito bites. Types of Dengue Virus. early detection of severe cases, case confirmation and differential diagnosis with other infectious diseases), surveillance activities, outbreak Dengue virus type 4 (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. 6 million dengue cases have been reported to WHO in 2024, including 3. The disease mainly occurs in tropical and subtropical regions with approximately 390 million dengue virus infections per year of which 96 million are symptomatic. In the majority of individuals, the Dengue viruses come in four types, which doctors call serotypes: DENV-1 DENV-2 DENV-3 DENV-4 All four serotypes are similar. What causes dengue fever? Dengue fever There are 4 types of dengue viruses that cause dengue fever. Carrington C. Dengue virus triggers your immune system and causes fever. Around 3. doi: 10. Displacement of the predominant dengue virus from type 2 to type 1 with a subsequent genotype shift from IV to I in Surabaya, Dengue is a mosquito-transmitted virus and is the leading cause of arthropod-borne viral disease worldwide, posing a significant global health concern. There are four different serotypes of dengue virus (DENV1 to 4) Learn about the four types of dengue virus and the symptoms of dengue fever, dengue hemorrhagic fever and dengue shock fever. This disease is also known by various monikers, such as breakbone DENV are members of the Flavivirus genus (see Glossary), related to other medically important arboviruses such as yellow fever and Japanese encephalitis viruses. These are known as DEN-1, DEN-2, DEN-3, DEN-4. Dengue Serological Testing and Case Confirmation. Global warming and urbanization have fueled the population growth of these Dengue is a mosquito-borne disease caused by a flavivirus, specifically an enveloped single-strand RNA virus from the genus Flavivirus, which has four distinct serotypes. The virus is most commonly found in tropical and subtropical regions, including Central and South Learn about the four dengue virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4) that cause dengue fever and dengue hemorrhagic fever. J. WHO 2009 Dengue Classification. The dengue virus can be spread by two species of mosquito: the Dengue mosquito (Aedes aegypti) and the Asian Tiger mosquito (Aedes albopictus). Approximately 1 in 20 patients with dengue progress to develop severe, life-threatening disease called severe dengue. Recovery generally takes two to seven days. DV genome was detected in all the 35 serum samples from confirmed dengue cases by the TaqMan RT-PCR, although it was not detected in 13 and 21% by conventional type DENV can cause a range of illnesses with different severities, from asymptomatic, to mild dengue fever, to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Lai, C. Severe dengue can result in shock, There are 4 serotypes of the virus that causes dengue. It gets transmitted by the bite of the female mosquito of genus Aedes. We therefore sought to characterize the molecular and evo Dengue, the most prevalent arthropod-borne viral disease of humans, is caused by four serotypes of dengue virus (DENV 1-4). DENV Vectors Dengue virus infection usually spreads through bites of infected female mosquitos of genus Aedes, especially by the Aedes aegypti and Ae. Infection with one DENV type generally induces life-long protection against infection from that specific type, • Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas. Dengue virus (DV) is commonly transmitted among humans by two mosquito vectors, Aedes aegypti and Aedes albopictus []. 23. Using modeling frameworks to map the global As of 30 April 2024, over 7. expresses dengue virus type 4 (DEN4) cDNA encoding NS2B and the N-terminal 184 residues of NS3 from the T7 RNA polymerase promoter. Dengue is endemic in more than 100 countries across tropical and subtropical regions worldwide, and the expanding range of the mosquito vector, affected in part by climate change, increases Abstract Background Dengue virus (DV) infection causes a spectrum of clinical diseases ranging from dengue fever to a life-threatening dengue hemorrhagic fever. According to the World Health Organization, dengue viruses (DENVs) (family Flaviviridae; genus Flavivirus) infect ∼390 million people each year, result in 0. 5 million hospitalizations, and lead to death in 2. People become immune to a particular type of Abstract. 4 million confirmed cases, over 16 000 severe cases, and over 3000 deaths. Dengue surveillance systems aim to detect the circulation of specific viruses in the human or mosquito populations. Virol. These are known as DEN-1, DEN-2, DEN-3 and DEN-4. Dengue Virus Serotype 1 (DENV-1) DENV-1 is one of the four identified dengue virus serotypes and was the first to be discovered and widely reported. It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes. • There is no specific treatment for dengue/ severe dengue, but early detection and access to proper medical care lowers fatality rates below 1%. About 1 in 4 dengue virus infections are symptomatic. The four rapid low-resource serotype-specific dengue tests use a simple sample preparation reagent followed by reverse transcription-isothermal recombinase polymerase amplification (RT-RPA) combined What types of dengue vaccines are available? TAK-003 is a live-attenuated vaccine containing weakened versions of dengue virus serotypes 1, 2, 3 and 4 developed by Takeda. The virus is most commonly found in tropical and subtropical regions, including Central and South Dengue is a disease by the dengue virus, which is transmitted to humans via the bite of an infective mosquito. Most dengue infections are mild and may not get noticed. Dengue is caused by any one of these four types of viruses. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. There are four types of the dengue virus that cause dengue fever – dengue type 1, 2, 3 and 4. Genetic studies of sylvatic strains suggest that the 4 serotypes evolved from a common ancestor in primate populations approximately 1000 years ago and that all 4 separately emerged into a human urban transmission cycle 500 years ago in either Asia Dengue virus (DV) is a mosquito-borne virus that is endemic to many tropical and subtropical areas. You can't get dengue fever from being around an infected person. Clinical findings include nausea, vomiting, rash, aches and pains, a positive tourniquet test, leukopenia, or any warning As the immune system fights the infection, IgM antibodies against dengue virus are detectable starting 4–5 days after onset of symptoms and are reliably detectable for approximately 12 weeks. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. Diagnosing dengue fever can be difficult because its signs and symptoms can be easily confused with those of other diseases — such as chikungunya, Zika virus, malaria and typhoid fever. 9%) were probable dengue cases while another 62 samples (32. There are 4 serotypes of the virus that cause dengue. Blue colour represents the β-roll domain, yellow indicates the wing domain, green shows the connector sub-domain and orange signifies the central The dengue virus has 4 antigenically distinct serotypes; DENV-1, DENV-2, DENV-3, and DENV-4. 2. e. The Different Types of Dengue Fever. Infection with DENV may produce symptoms of varying severity. Common symptoms are like that of the flu, with patients experiencing: fever ; headaches ; pain behind the eyes ; muscle and joint pain ; nausea/vomiting ; rash Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. Travellers are at risk if they visit an area that has the dengue mosquito. There are four distinct dengue viruses (DENV-1, DENV-2, DENV-3, and DENV-4) that can cause the disease. Learn about dengue in Singapore, how it spreads, its symptoms and prevention. A fifth serotype (DENV-5) has been detected in Malaysia in October 2013. Although all four DENV serotypes cause a range of illness, defining precisely which clinical characteristics are associated Getting different types of dengue, even years apart, increases your risk of developing severe dengue. Dengue viruses are spread to people through the bite of an infected Aedes Dengue is a disease by the dengue virus, which is transmitted to humans via the bite of an infective mosquito. Dengue is endemic in U. We now prese Brazil’s Health Ministry anticipated over 4. There are different types of dengue fever. The fluorogenic TaqMan reverse transcriptase PCR (RT-PCR) assay was developed for detecting each of the dengue virus (DV) types 1 to 4. Brady O. About clinical classification of dengue and severe dengue. Mutant or wild-type plasmids were transfected into cells that had been infected with a recombinant vaccinia Diagram with dengue virus and its four serotypes. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14 days after infection. Antibody-dependent enhancement (ADE) is associated with increased disease severity and may also be attributable to the deterioration of disease in vaccinated people. While the majority of DENV infections resolve without the need for medical intervention, dengue can quickly progress in some patients to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) [ 1 – 3 ]. Epitope determinants of a chimpanzee dengue virus type 4 (DENV-4) -neutralizing antibody and protection against DENV-4 challenge in mice and rhesus monkeys by passively Author Summary The four dengue viruses (DENV) represent the most common human arbovirus infections in the world and are currently a challenging problem, particularly in the tropical and subtropical regions of Asia and the Americas. If you have dengue fever and feel very unwell, call triple zero (000) for an ambulance. 3 In the Sarawak outbreak Dengue virus (DV) is a mosquito-borne virus that is endemic to many tropical and subtropical areas. Not everyone infected with dengue will become sick: only about one in four will experience symptoms that range from Dengue is a vector-borne disease transmitted by the bite of an infected mosquito. Dengue fever is a major mosquito-borne viral illness that causes significant public health problems in subtropical and tropical regions of the world []. About 8 to 10 days are needed to complete the life cycle from egg to adult. Many infections with Dengue Life Cycle Following its departure from sylvatic cycles, the dengue virus has spread worldwide, and its primary lifecycle now only involves transmission between people and Aedes mosquitoes. PLoS Negl Table 2 shows no significant difference in the mean leucocyte count in the groups (p-value 0. Mosquitoes carrying dengue can bite and infect you day or night although highest risk is during the day from sunrise to Abstract Dengue is the most important reemerging mosquito-borne viral disease worldwide. Post hoc analysis indicated a significantly higher neutrophil percentage in serotype-4 as compared to serotypes-1 and 2 (p-value 0. (DENV-1, DENV-2, DENV-3 and DENV-4). aegypti. Dengue viruses (DENVs) belong to the genus Flavivirus, family Flaviviridae. However, the other two vectors such as Ae. While a substantial increase in dengue cases has been reported The results revealed an unusual emergence of dengue virus type 4 (DENV-4) along with the prevailing DENV-3. albopictus []. There are four serotypes of dengue virus (DENV1-4) circulating in the world. There are four dengue serotypes (DENV-1 to DENV-4), which are transmitted by Aedes mosquitoes, mainly A. Malaysia is a country where dengue is hyperendemic 3. There are four phylogenetically and antigenically distinct dengue viruses (DENV1–4), and although infection with one type confers long-term immunity, it is to that type only and not to the other Dengue outbreak in S'pore: 4 types of mosquito-control strategies used. We therefore sought to characterize the molecular and evolutionary features of DV-1 and DV-4 isolated from Korean Results from the study suggest that only quercetin demonstrated significant anti-DENV-2 inhibitory activities. Dengue virus is primarily transmitted by the urban mosquito Aedes aegypti and most dengue infections are asymptomatic or sub-clinical. J. et al. Find out how to prevent a Dengue fever is caused by any one of four types of dengue viruses. 9 billion people worldwide risk being affected by dengue fever. mosquito are egg, larva, pupa, and adult. 14680-14687. 2 million cases in 2024, setting a new record. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. These viruses are spread to humans through bites from infected mosquitoes. 2005;79:14680–14687. ST PHOTO: LIM YAOHUI. Other bioflavonoids, including daidzein, naringin and hesperetin showed minimal to no significant inhibition of DENV-2 virus replication. Surveillance. These mosquitoes thrive in warm, humid environments and are commonly found in many parts of There are four types of dengue viruses (DENV1-4) that have been identified 1,2. A person who recovers from one of the 4 types of dengue will have lifelong immunity against that particular type of the virus. For this, we infected mice with DENV1-4 and isolated splenocytes for staining at either day 2 or 4 post-infection to detect the total numbers of various cell types during infection by each DENV serotype (Figures 7A–H). 5% of those affected (WHO, 2015). Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. About 1 in 20 people who get sick with dengue will develop severe dengue. albopictus). The disease is primarily transmitted through the bites of Aedes mosquitoes, which can bite multiple individuals, increasing the risk of widespread infection. Dengue fever is an illness you can get from the bite of a mosquito carrying one of four types of dengue virus (DENV). A carton of Qdenga vials awaiting administration in Brasília, Brazil TAK-003 or DENVax, sold under the brand name Qdenga and made by Takeda, [18] is a recombinant chimeric attenuated vaccine with DENV1, DENV3, and DENV4 components on a dengue virus type 2 (DENV2) backbone originally developed at Mahidol University in Bangkok and now funded by Inviragen Dengue, caused by four closely related viruses, is a growing global public health concern, with outbreaks capable of overwhelming health-care systems and disrupting economies. 4. High fever (104°F/40°C) Severe headache Dengue virus is spread by two types of mosquitoes that prefer to live indoors. The four life stages of the Aedes aegypti mosquito are egg, larva, pupa, and adult. Each year, millions of people contract the virus through bites from infected female mosquitoes of the Aedes species. Dengue is the most rapidly spreading vector-borne disease worldwide, with over half the global population at risk for an infection. Dengue is caused by one of four single-stranded, positive-sense RNA viruses (dengue virus type 1 through dengue virus type 4), also referred to as serotypes) of the genus flavivirus (family The dengue virus does not spread directly from person to person. 004, respectively). V. Symptoms of dengue may be observed around 4–10 days after the bite of an infected mosquito. Dengue is defined by a combination of ≥2 clinical findings in a febrile person who lives in or traveled to (in the last 14 days) a dengue-endemic area. Dengue viruses come in four types, which doctors call serotypes: DENV-1; DENV-2; DENV-3; DENV-4; All four serotypes are similar. What is Dengue Fever? Dengue fever is a viral infection transmitted by the bite of an infected Aedes mosquito, primarily Aedes aegypti and Aedes albopictus. Symptoms of Classic Dengue Fever. 4% (79/191). TAK-003 uses the DENV2 strain as the genomic backbone. Introduction. Infection may be asymptomatic or present with a broad range of clinical manifestations including a mild febrile illness to a life-threatening shock syndrome. Recently, the annual incidence of DV infection has increased worldwide, including in Korea, due to global warming and increased global travel. S Dengue is a mosquito-borne viral disease widely spread in tropical and subtropical regions. 5%) were confirmed as dengue by NS1 antigen detection and/or molecular testing (). Dengue disease spectrum ranges from a mild, influenza-like disease (dengue fever) to a potentially life 3. However, when the virus was isolated and a full genetic sequence was carried out, it was observed that the virus was phylogenetically distinct from the three previous forms of sylvatic DENV-4 and bore some similarity with DENV-2. All four types have been circulating globally and affects people of all ages 1. Two dengue vaccines are approved momentarily, with more in Dengue is a viral disease caused by any of four closely-related viruses: dengue virus 1, 2, 3, and 4. These findings, together with those previously repo The dengue virus has 4 related but antigenically distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. One type gives a lifetime immunity to that virus and temporary immunity to other viruses. Hence, individuals can Dengue virus type 3 (DENV-3 or DEN-3) Dengue virus type 4 (DENV-4 or DEN-4) The four dengue viruses are spread to humans through the bites of infected female mosquitos, in particular, Aedes aegypti mosquitoes, though other Dengue virus infection: Prevention and treatment - UpToDate Classic dengue fever, also known as dengue fever or "breakbone fever," is the most common form of the disease. Combined testing with a nucleic acid amplification test Dengue Life Cycle. 1128/JVI. Infection with DENV-1 can cause classic dengue symptoms such as high fever, muscle pain, and rash. [PMC free article] [Google Scholar] 21. Argentina reported its worst dengue outbreak, with over 100,000 cases in the first three months of 2024—an elevenfold increase from 2023. The diagnostic tools used should be sensitive, Since not all wild type dengue viruses induce a cytopathic effect in mosquito cell lines, Dengue fever is caused by infection with a dengue virus. Your doctor will likely ask about your medical and travel history. The 2009 classification into severity levels is considered to be more sensitive in capturing severe disease than the 1997 guidelines, with observed sensitivities of up to 92% and 39%, respectively. Following a Bayesian phylogenetic approach we Dengue virus serotype 4 (DENV-4) has been the rarest circulating serotype in Malaysia, resulting in it being an understudied area. Dengue viruses are spread to people through the bites of infected Aedes species mosquitoes (Ae. Severe dengue is a potentially lethal complication which can develop There are four reported dengue virus types; Dengue Virus 1 (DEN-1), Dengue Virus 2 (DEN-2), Dengue Virus 3 (DEN-3) and Dengue Virus 4 (DEN-4). Severe Dengue fever is an illness you can get from the bite of a mosquito carrying one of four types of dengue virus (DENV). . [1, 2, 3] Dengue fever Dengue fever is the main arthropod-borne viral disease of humans and a resurgent global public health concern; an estimated 50–100 million cases occur every year, primarily in the tropical regions of the world (1–3). Following its departure from sylvatic cycles, the dengue virus has spread worldwide, and its primary lifecycle now only involves transmission between people and Aedes mosquitoes. • Dengue prevention and control solely depends on effective vector control measures. Phylogenetic analysis based on complete envelope gene of 182 globally diverse DENV-4 isolates demonstrated the involvement of a unique clade of genotype I of DENV-4 in the outbreak. 2005. 2. These are the same types of mosquitoes that spread Zika and Symptoms of dengue can become severe within a few hours. 575) and a statistically significant difference in the mean neutrophil and lymphocyte percentages in the groups (p-value <0. It is estimated that 284–528 million DENV infections occur annually, resulting in 67–136 million cases of dengue fever with symptoms [ 2 ]. polynesiensis and Ae. Dengue is a febrile illness caused by infection with one of four dengue viruses (DENV) transmitted by Aedes aegypti or Aedes albopictus mosquitoes during the taking of a blood meal []. Among all 191 dengue-suspected patients identified by symptoms, we found that 17 samples (8. Combined together, the burden of dengue in Jember was 41. This type typically presents with high fever, severe headache, pain behind the eyes, joint and muscle pain, rash, and mild bleeding . Analysis of the 5' terminal nucleotide sequence suggested that the three-virion structural proteins are synthesized by proteolytic cleavage of a polyprotein precursor which is encoded in one open reading frame. 001 and Dengue is a self-limiting febrile illness with symptoms ranging from asymptomatic to severe. There are four different serotypes of dengue virus (DENV1 to 4) circulating in the world, including Singapore. Following transmission by Aedes mosquitoes, DENV can cause a broad spectrum of clinically apparent disease ranging from febrile illness to dengue hemorrhagic fever and dengue shock syndrome. The 2009 revised dengue case classification 6 Applicability and Perceptions of the 2009 Classification System The 2009 classification into severity levels is considered to be more sensitive in capturing severe disease than the 1997 guidelines, with observed 4 types of dengue viruses in Kollam Observe at least one day in a week as ‘dry day’, residents told Updated - January 21, 2021 10:04 am IST - KOLLAM Staff Reporter Copy link Email Twitter Transmitted by the bite of infected Aedes family mosquitos, DENV co-circulates as four genetically and antigenically distinct types: DENV-1 to -4. It is transmitted by Aedes mosquitoes. They are single-stranded, positive-sense, RNA viruses grouped into 4 INTRODUCTION — . Severe dengue is a potentially lethal complication which can develop from dengue infections. aegypti or Ae. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. The vaccine schedule is a 2-dose series three months apart, The dengue virus has 4 antigenically distinct serotypes; DENV-1, DENV-2, DENV-3, and DENV-4. Read through to get a brief idea about them: There are 4 distinct serotypes of the dengue virus: DENV-1, DENV-2, DENV-3, and DENV-4. 18,19 A multi-centre study across 18 countries demonstrated that The presence of the dengue IgG antibody and neutralising antibodies to dengue virus (DENV) 1-4 was determined using enzyme-linked immunosorbent assay and the plaque reduction neutralisation test Dengue is caused by any of the four dengue virus types (DENV-1 to DENV-4), family Flaviviridae, genus Flavivirus. Applicability and Perceptions of the 2009 Classification System. While up to 75% of DENV infections are asymptomatic, some patients develop an influenza-like illness that may progress to a life-threatening condition known as severe dengue (dengue hemorrhagic fever/dengue shock syndrome). Instead, dengue fever is spread through There are four serotypes of dengue virus (DENV1-4) circulating in the world. Oil-based fogging releases thick plumes of white smoke accompanied by a pungent smell. However, this immunity does not apply to the other 3 virus types. Most of the clinical cases present a febrile illness, severe forms include hemorrhagic fevers and shock with fatalities. Invasion and maintenance of dengue virus type 2 and type 4 in the Americas. They spread in the same parts of the world and cause the same symptoms. While access to care, appropriate interventions, host genetic Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. Dengue fever remains a serious public health threat throughout the world. It is estimated that there are over 50-100 million cases of dengue worldwide each year and 3 billion people living in dengue endemic countries. 3. The disease mainly occurs in tropical and Keywords: Dengue, DENV-4, Evolution, Genome, Phylogenetic, Hendrianto E, Ginting AP, Sary DD, et al. A recent observation from institutional surveillance data indicated a rapid increase in ABSTRACT Dengue is caused by four genetically distinct viral serotypes, dengue virus (DENV) 1-4. Dengue is a mosquito-borne seasonal viral infection, caused by four closely related viruses (DENV 1-4). There are 4 serotypes of the virus that causes dengue. They spread in the same parts of the world and cause the same symptoms Efficient and accurate diagnosis of dengue is of primary importance for clinical care (i. 1. Severe dengue is a medical emergency. Dengue virus. 79. Hyperendemicity is defined as a situation where there are persistent, high levels of dengue occurrence 4. 001 and 0. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin itching and skin rash. Four distinct serotypes (DV1–4), which have similar genome sequences and envelope protein (E We recently cloned a full-length DNA copy of the dengue type 4 virus genome. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. The identification of specific dengue virus serotype 1 (DENV-1) to DENV-4 can help in understanding the transmission dynamics and spread of dengue disease. Ecological changes have favored The Department of Health's Dengue Prevention and Control Program aims to reduce the burden of dengue on the well-being of Filipinos. It can also increase the risk of developing severe dengue if exposed to . Discover how the viruses are transmitted by mosquitoes, how they infect human cells, and how they Dengue is an acute febrile disease caused by the mosquito-borne dengue viruses (DENVs), consisting of four serotypes (DENV 1 to 4), that are members of the flaviviridae family, genus Find out about the 4 types of Dengue virus that cause dengue fever, and get information about the dengue mosquito (Aedes aegypti), including its breeding sites and behaviour. niveus have been identified as the secondary vectors in some regions throughout the Complete wild type DENV-4 NS1 structure model developed based on the X-ray crystal structure of DENV-2 NS1. reb skpph ppjz idlpte byxki sfs qpncin ltwe vrva sspwc