Atrophic scarring eds. The skin is fragile, as manifested … Hypermobile EDS.

Atrophic scarring eds One feature seen across all types of EDS is skin hyperextensibility, which means the skin can stretch beyond the normal range. Skin fragility with extensive atrophic scarring Very stretchy skin with velvety or doughy Small atrophic (thinned) scars may follow trauma at sites such as the forehead, chin, elbows, knees and shins. I have some tips in regards to reducing/eliminating scar appearances (not really specific for atrophic) which I can share if you want. Classical EDS (cEDS) is characterized by the presence of three major criteria: skin hyperextansibility, atrophic scarring and generalized joint hypermobility and 9 minor criteria Ehlers Danlos syndrome (EDS) is a group of hereditary connective tissue disorders that manifests clinically with skin hyperelasticity, hypermobility of joints, atrophic scarring, and fragility of blood vessels. However, even in the common conditions healing may be Classic Ehlers-Danlos syndrome (cEDS) is a heritable connective tissue disorder characterized by skin hyperextensibility, atrophic scarring, and generalized joint hypermobility (GJH). It has been noted in Skin that can be stretched further than it should is easily torn, and doesn’t repair itself well, causing disfiguring scarring. Given the range of skin responses in EDS, individual experiences can vary widely. However, in contrast to I only have atrophic scarring on my really big/deep wounds. Classic Ehlers-Danlos syndrome (cEDS) is a heritable connective tissue disorder characterized by skin hyperextensibility, atrophic scarring, and generalized joint hypermobility (GJH). Premature aging of the skin Some people with p EDS notice signs of skin aging earlier than usual, particularly on their hands and feet. , thin and sunken) and/or wider than The E hlers-D anlos s yndromes (EDS) are a group of 13 heritable connective tissue disorders. Hypotonia improves with age but, in For example, someone with generalized joint hypermobility and chronic pain may also have features of hypermobile EDS such as atrophic scarring, stretch marks, hernias, and rectal prolapse, but they do not meet the 2017 diagnostic criteria. Typical clinical manifestations are skin hyperelasticity, hypermobility of joints, the fragility of blood vessels, and atrophic scarring. Patients are affected with joint hypermobility, skin hyperextensibilty, and skin fragility leading to atrophic scarring and significant Ehlers-Danlos syndrome (EDS) is a rare, genetically variable, heterogenous group of (currently recognized) thirteen connective tissue disorders characterized by skin hyperextensibility, tissue fragility, and generalized joint hypermobility. Pretibial plaques. The skin is fragile, as manifested Hypermobile EDS. Find out how to manage the skin and avoid scarring or complications in surgery. This EDS subtype also greatly affects the joints, causing joint hypermobility, most commonly affecting the shoulders and ankles, and recurrent joint dislocations. 2. Widened atrophic scarring. Classical EDS (cEDS) Classical EDS is the next-most-common form of the condition. e. Type V collagen. There are overlapping clinical features with TNXB-related classical-like EDS (or clEDS type 1), including skin hyperextensibility, joint hypermobility, and easy bruising. TABLE 1 (continued) Overlap between Joint Hypermobility, Hypermobility Spectrum Disorders, and Ehlers-Danlos Ehlers-Danlos syndromes (EDS) are a group of connective tissue disorders associated with skin, ligament, blood vessel and organ abnormalities. Skin fragility with extensive atrophic scarring; Very stretchy skin with velvety or doughy texture; COL5A2. Recurrent/chronic dislocations; Pectus deformities (flat, excavated) DSE associated musculocontractural EDS, a milder phenotype or phenotypic Tampa, Florida, and the mother of an EDS child. for heds, the criteria requires "Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS" and atrophic scarring is "defined as scars from linear traumatic lacerations or single-surgery that are unusually shallow (i. The Ehlers Common presenting features of hypermobile EDS are listed in Table 2. After performing an exhaustive online search for this information, I encountered one individual who warned strongly against the use of silicone sheeting on atrophic scars, claiming that they make Ehlers–Danlos syndrome (EDS) is a heterogeneous group of inherited disorders of connective tissue that variably impairs the structure and function of the skin, joints, internal organs, eyes and blood vessels. Atrophic scarring involving at least two sites and without the formation of papyraceous and/or hemosideric scars as seen in classic EDS. Marfanoid features: The Ehlers-Danlos syndromes (EDS) are a group of heritable, connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Hence, this study reported a case of cEDS with both clinical manifestations and COL5A2 gene mutation. In addition, atrophic scarring delayed wound healing has important implications regarding ophthalmic Vascular Ehlers-Danlos syndrome (EDS) is a relatively rare genetic syndrome that occurs owing to disorders in the metabolism of fibrillary collagen. Vascular complications, though rare in classical EDS, can be life-threatening, and this necessitates one to look for vascular The skin has an amazing ability to heal, but it is not always perfect. Vascular EDS (vEDS Unlike classical EDS, atrophic scarring is not present in classical-like EDS. It is Classic Ehlers-Danlos syndrome (cEDS) is a heritable connective tissue disorder characterized by skin hyperextensibility, atrophic scarring, and generalized joint hypermobility (GJH). A healing scar in a 6-year-old girl (a); a papyraceous, non-hemosiderotic scar in a 22-year-old female (b); a cigarette paper scar in a 39-year-old female (c); multiple papyraceous, hemosiderotic scars in a 40-year-old female (d); multiple papyraceous scars in a 57-year-old Some defects in the most amino-terminal region of either the α1(I)- or the α2(I)-collagen triple helix have been shown to result in a EDS/OI overlap phenotype, characterized on the one hand by joint hypermobility, skin hyperexentibility with mildly atrophic scarring, and easy bruising and on the other hand by a variable degree of bone Making a diagnosis of classical Ehlers-Danlos syndrome (cEDS) It is often possible to make a diagnosis of classical EDS from a clinical examination together with details of a person’s medical history, however a genetic test is helpful to confirm a diagnosis. organizations, and support groups. There are currently nine reported individuals with AEBP1 People with cvEDS also have other symptoms, such as joint hypermobility, skin hyperextensibility, and atrophic scarring. [164] It was originally notated in the Peruvian Paso and thought to be a condition of overwork and older age, but it is being recognized in all age groups and all activity levels. Type I collagen. The clinical features to look for include: Fragile skin which can split easily with [] In addition to skin hyperextensibility and joint hypermobility, patients with EDS can present with easy bleeding/bruising, atrophic scarring, aortic root dilation, mitral valve prolapse, gastrointestinal complications, scoliosis, and chronic joint pain, among other concerns. Degenerative suspensory ligament desmitis is a similar condition seen in many breeds of horses. Joint dislocations occur in around 75% of all patients with EDS. Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS; Pelvic floor, rectal, and/or uterine prolapse in children, men or nulliparous woman without a history of morbid obesity or other known predisposing medical condition; EDS (mEDS) Congenital muscle hypotonia, and/or muscle atrophy (improves with age) Proximal joint contractures (knee, hip and elbow) Hypermobility of distal joints • Soft, doughy skin • Atrophic scarring • • Myopathy on muscle biopsy Periodontal EDS • (pEDS) Severe and intractable periodontitis of early onset (childhood or adolescence) The clinical features of TNXB-related classical-like Ehlers-Danlos syndrome (clEDS) strongly resemble those seen in classic EDS (cEDS). 1 Since EDS patients can present with such a variety of symptoms, the erns: A 30-year-old female presented to the plastic-surgery clinic with widen atrophic scars on forehead, elbows, knees and pretibial area that had developed since childhood. Elastoma Ehlers Danlos Syndrome (EDS) is a underdiagnosed connective tissue disorder characterized by a genetic fault in collagen. People with milder symptoms may find they Ehlers-Danlos syndrome (EDS) refers to a group of genetic connective tissue disorders. They can also stretch and look more wide. More than 95% of people with hEDS Atrophic scarring Arterial rupture Respiratory compromise in severe cases: PLOD1 FKBP14: Affects folding and cross-linking of collagen: Myopathic EDS: Congenital muscle weakness and atrophy, lessening with age Contractures of proximal joints Joint hypermobility Developmental motor delay: COL12A1: Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS**. These defects affect the soft connective tissues resulting in A form of Ehlers-Danlos syndrome (EDS) characterized by congenital bilateral hip dislocation, severe generalized joint hypermobility with recurrent joint dislocations and subluxations, hyperextensible and/or fragile skin. The skin is soft, velvety, or doughy to the touch. Signs and Symptoms . Atrophic scarring is defined as scars from linear traumatic lacerations or single surgery that are unusually shallow and/or Atrophic scarring involving at least two sites and without the formation of truly papyraceous or haemosideric scars as seen in classical EDS Pelvic floor, rectal, and/or uterine prolapse in children, men, or nulliparous Minor trauma can cause large wounds that result in atrophic scarring from a young age in people with cEDS. Skin hyperextensibility, joint hypermobility and widened atrophic scars are characteristic of classical EDS. In addition, the skin is hyperextensible, meaning that it extends easily and snaps back after release. Vascular Ehlers-Danlos Syndrome (vEDS) This is one of the most severe Ehlers-Danlos Classical EDS - associated with skin hyperextensibility, smooth skin that is fragile and bruises easily; wide, atrophic scars (flat or depressed scars); and joint hypermobility molluscoid pseudotumors (calcified hematomas over pressure points such as the elbow) and spheroids (fat-containing cysts on forearms and shins) occur frequently Like classical EDS, it is characterized by skin hyperextensibility and generalized joint hypermobility (often affecting the small joints of the hands) with or without dislocations (most commonly ankle and shoulder). It manifests as hypermobile joints and affects every organ system because we’re all made of connective tissue! Ehlers Danlos syndrome (EDS) is a group of hereditary connective tissue disorders that manifests clinically with skin hyperelasticity, hypermobility of joints, atrophic scarring, and fragility of blood vessels. Diagnosis: With the skin hyperextensibility, joint hypermobility, papyraceous scar revealed by physical examination, and the heterozygous pathogenic variant c1997G > A (p. 23 Palmar wrinkling, atrophic scarring, marked bruising with subcutaneous haematomas, soft doughy skin and postnatal growth retardation with short limbs, hands and feet may also be Ehlers-Danlos Syndrome (EDS) is a group of connective tissue disorders characterized by a wide range of symptoms, many of which prominently affect the skin. Apart from normal skin healing, there are three main types of scars that can occur on the skin: atrophic, here's the definition of atrophic scarring from the 2017 criteria. 16 Atrophic scarring is defined as scars from linear traumatic lacerations or single-surgery that are unusually shallow (i. Cookie Duration Description; _ga: 2 years: The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. Vascular Ehlers–Danlos syndrome (vEDS) The scar does not necessarily need to be a sutured wound. 'Atrophic scarring is defined as scars from linear traumatic lacerations or single-surgery that are unusually shallow (i. tissue weakness, and atrophic scarring (indented and imbalanced scarring below normal layers of skin because the skin is unable to generate An estimated 60% of individuals have widened atrophic scarring. , thin and sunken) and/or wider than the original wound due to impaired Download scientific diagram | Widened atrophic scarring and smooth and velvety skin, characterizing from publication: Ehlers–Danlos Syndrome in an Adult Woman: A Hidden Sindrome | Ehlers . Bruising occurs easily in all individuals, and severe bruising occurs in approximately 50%. These visible and tactile skin changes not only contribute to the diagnostic Delayed wound healing and atrophic scarring may be prominent in EDS, especially in the classic type, and rarer subtypes, such as the kyphoscoliotic and arthrochalasia type. " I do have 2 of these types of scars (one from surgery, one from facial blemish), but the vast majority of my scars are mild keloids or hypertrophic scars. Most patients have widened atrophic scar at forehead, elbow, knee and Classical-like EDS (clEDS) characterized by skin hyperextensibility with velvety skin texture and absence of atrophic scarring, generalized joint hypermobility (GJH) with or without recurrent dislocations (most often shoulder and ankle), and easily bruised skin or spontaneous ecchymoses (discolorations of the skin resulting from bleeding Atrophic scarring involving at least two (2) sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS Pelvic floor, rectal, and/or uterine prolapse in children, men or nulliparous women without a history of morbid obesity or other known predisposing medical condition ¨ Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS ¨ Pelvic floor, rectal, and/or uterine prolapse in children, men or nulliparous women without a history of morbid obesity or other known predisposing medical condition Ehlers Danlos syndrome (EDS) is a group of hereditary connective tissue disorders which manifests clinically with skin hyper-elasticity, hypermobility of joints, atrophic scarring, and fragility of blood vessels. Easy bruising and atrophic scarring may also be present, but are not severe. Hypermobility A) Representative images of different atrophic scars on cEDS patients’ knees. [1][2] It The clinical features of TNXB-related classical-like Ehlers-Danlos syndrome (clEDS) strongly resemble those seen in classic EDS (cEDS). However, significant or severe scarring is not a feature of hEDS. Ehlers-Danlos syndromes (EDS) are an inherited heterogeneous group of connective tissue disorders characterized by an abnormal collagen synthesis affecting skin, ligaments, joints, blood vessels, and other organs. Classical EDS is a heritable disorder of connective tissue. Fatigue Is there any hope for my atrophic scarring? Vent I have two pretty unsightly atrophic scars on my legs, one from a mole removal and one from an injury. classic-like EDS (clEDS): similar to classical EDS but lacks atrophic scarring (mutations in TNXB) What are the common symptoms of EDS? joint hypermobility (increased joint movement) skin hyperextensibility (stretchy skin) fragile tissues that bruise easily or heal poorly; Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS; Pelvic floor, rectal, and/or uterine prolapse in children, men or nulliparous women without a history of morbid obesity or other known predisposing medical condition; Other symptoms may include. Recurrent or multiple abdominal hernia. I am currently seeking a diagnosis and I am not sure if I have atrophic scarring or not. So expect it to take longer to heal. There are also several other distinguishing clinical findings Ehlers–Danlos syndrome (EDS) is a heritable connective tissue disorder. Classical EDS (cEDS) Very stretchy skin Introduction: AEBP1-related classical-like EDS (clEDS type 2) is a rare type of Ehlers–Danlos syndrome (EDS) that was first reported in 2016. It is largely diagnosed clinically, although identifying the gene encoding the col Atrophic scarring involving at least two sites and without the formation of papyraceous and/or hemosideric scars as seen in classic EDS. Cutaneous stretchibility (hyperextensibility) They can occur without EDS and are caused by reversible herniation of the underlying fat into the dermis. The ones on my knee are almost ten years old from scraping against a bit of rocky cement. There’s enough variance to Eds scarring that speaking to an artist might get you better answers Reply reply Atrophic scars represent some of the most difficult and insidious pathologies confronting the reconstructive surgeon. I think you're best consulting a dermatologist honestly Ehlers-Danlos Syndrome (EDS) is a group of connective tissue disorders that are generally inherited and are varied both in their genetic causes and how they affect the body. Pelvic floor, rectal, and/or uterine prolapse in children, men or nulliparous women without predisposing medical condition. EDS affects 1 in 5,000 people worldwide, according to the National Library of Medicine’s Genetics Home Reference. hEDS is the Ehlers Danlos syndrome (EDS) is a group of hereditary connective tissue disorders that manifests clinically with skin hyperelasticity, hypermobility of joints, atrophic scarring, and fragility of blood vessels. 1, 2, 21 The prevalence of generalized joint hypermobility declines with age, 2 and this decline is considered by the 2017 EDS in the same dog showing an atrophic scar. This genetic disorder presents itself with extremes of hypermobile joints and stretchy and fragile skin. I'm at a 50/50 shot with this so far left arm is shiny in areas right arm tattoo is fine. Deriving from the ancient Greek “a-trophos” (wasted), the term presents a vivid representation of the clinical picture and an area of scar management particularly worthy of specific attention. The skin is fragile, as manifested Ehlers-Danlos syndrome is a group of inherited connective tissue disorders that primarily affects the skin, joints, and blood vessel walls1 but can affect every organ system and result in significant morbidity and mortality. I called them to ask what would happen if I used them on an atrophic scar, and they had no idea, as they were unfamiliar with that type of scarring. The conditions are caused by genetic changes that affect connective tissue. 80 Instability may be seen in most clinical EDS subtypes (classic, classic-like, hypermobile, cardiac valvular, EDS/osteogenesis imperfecta overlap syndrome, arthrochalasia), though patients with hypermobile-type EDS (hEDS) are particularly prone. It is largely diagnosed clinically, although identification of the gene encoding the collagen or proteins interacting with it is necessary to identify the type of EDS. 23 Palmar wrinkling, atrophic scarring, marked bruising with subcutaneous haematomas, soft doughy skin and postnatal growth retardation with short limbs, hands and feet may also be Looking at the EDS criteria (I'm in the process of being diagnosed), it says "atrophic scarring. In dermatosparaxis EDS (dEDS), the skin is extremely and prematurely fragile with congenital or postnatal tears and sagging around the wrists and ankles (Figure 3b). Affected individuals have generalized joint hypermobility, hyperextensible skin, and easy bruising, but do not have atrophic scarring, as is seen in cEDS. And not every scar is atrophic. It is highly improbable to have more than Classic Ehlers-Danlos syndrome is a heritable connective tissue disorder characterized by skin hyperextensibility, fragile and soft skin, delayed wound healing with formation of atrophic scars Classical EDS is the second most common subtype of EDS and is characterized by skin hyperextensibility, atrophic scarring, and impaired wound healing. There is no atrophic scarring in clEDS. , thin and sunken) and/or wider than the original wound The minimal criteria suggestive of cEDS are skin hyperextensibility plus atrophic scarring together with either generalized joint hypermobility and/or at least three of the following minor criteria: easy bruising, soft/doughy skin, skin fragility, molluscoid pseudotumors, subcutaneous spheroids, hernia, epicanthal folds, complications of joint hypermobility, family history of a first degree The clinical features strongly resemble classical EDS (cEDS) with two key differences: (1) the absence of atrophic scarring and (2) autosomal recessive inheritance. The most catastrophic subtype is vascular EDS, which is associated with blood vessel rupture and visceral perforation, and may have life-threatening consequences. Any break in the skin, including a surgical incision, can cause a scar. Hypertrophic scars are more common in my experiences, and it's when the scar heals over so theres a raised bump. This review summarizes the cutaneous features and adjunct investigations of EDS subtypes, including atrophic 4. Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS1 Atrophic scarring is defined as scars from linear traumatic lacerations or single-surgery that are unusually shallow (i. Each type of EDS has its own set of features with distinct diagnostic criteria. For EDS folks this is due to the elasticity of the skin and the compromised connective tissue in the epidermis region. Also atrophic scaring can leave ur tattoo with a reflective look in some areas. Skin changes (stretchy skin, atrophic scars, easy bruising) fragile skin with atrophic scaring) Periodental EDS (pEDS) Severe and intractable periodontitis of early onset. The information contained in this educational guide is intended primarily for educators, teachers, and parents of children affected poor wound healing, atrophic scarring . Atrophic scarring is a sign that skin is more fragile than normal and does not heal correctly. . Mild skin hyperextensibility may occur in people with any type of EDS. The skin is soft, velvety, or doughy to Ehlers Danlos syndrome (EDS) is a group of hereditary connective tissue disorder s which manifests clinically with skin hyper-elasticity, hypermobility of joints, atrophic scarring, and fragility of blood vessels. Each type of EDS is caused by pathogenic variants of genes that provide the instructions for making connective tissue proteins. Is it common to have hypertrophic scars with EDS instead? Thanks! 2. • Atrophic scarring involving at least two sites without the formation of papyraceous and/or hemosideric scars • Pelvic floor, rectal and/or uterine prolapse in There are shared features with previously reported individuals, including hypermobility (11/11), skin hyperextensibility (11/11), presence of atrophic scarring (9/11), and easy bruising (10/11). It Atrophic scarring involving at least two (2) sites and without the formation of truly papyraceous and/or hemosideric scars as seen in classical EDS; Pelvic floor, rectal, and/or uterine prolapse in children, men or nulliparous women without a In dermatosparaxis EDS (dEDS), the skin is extremely and prematurely fragile with congenital or postnatal tears and sagging around the wrists and ankles (Figure 3b). Post-traumatic, atrophic, and widened scar in a young man (A). Key signs and symptoms of cvEDS include: chain and an EDS/OI clinical phenotype (Nicholls et al. Lack of attached gingiva. They change color throughout the day but can go from a pale pink to a deep purple. Atrophic is basically that but the opposite/inverse. Affected individuals have generalized joint hypermobility, hyperextensible skin, and easy bruising, but do not have atrophic scarring, as Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosiderotic scars as seen in classical EDS. , 2001) https: Atrophic scarring means the scar is lower than the normal skin level. Cardiac-valvular Ehlers–Danlos syndrome (cvEDS) Patients with cvEDS present with minor signs of EDS but have severe aortic defect/cardiac valve involvement requiring surgical intervention. , thin and sunken) and/or wider than the original wound due to Classical EDS is the second most common subtype of EDS and is characterised by skin hyperextensibility, atrophic scarring, and impaired wound healing. Atrophic scarring; Recurrent large subcutaneous hematomas; Joint hypermobility and instability easy bruisability, skin fragility with atrophic scars, increased palmar wrinkling; Minor Criteria. Atrophic scarring is defined as scars from linear traumatic laceration(s) and/or surgical incision(s) that are unusually shallow and/or wider than the original wound. COL1A1. I had surgery in January and now when I run my fingers over them it feels like they sink into my skin rather than being raised. Atrophic scarring involving at least two sites and without the formation of truly papyraceous and/or hemosideric scars as seen inclassical EDS predisposing medical condition Dental crowding and high or narrow palate (i) positive wrist sign (Walker sign) on both sides, (ii) positive thumb sign (Steinberg sign) on both sides Atrophic scars are scars that have widened and become thin, causing them to appear sunken. From fragile, easily bruised skin to distinctive scarring and hyperextensibility, the skin serves as a critical diagnostic feature in many EDS subtypes. Atrophic scarring and bruising. Foot and hand deformities, peripheral edema, polyneuropathy, and mild myopathy can be noted as well. cEDS is a rare condition that affects roughly 1 in 20,000 – 40,000 people. that's totes normal. I hope this helps. Atrophic scars, especially of the knees and shins are also common due to skin fragility, but scarring is generally narrower than in cEDS. Each type is a distinct entity and may have very specific and unique features . More severe skin hyperextensibility is Classical Soft, velvety, doughy, and hyperextensible skin; thin (atrophic) scars, especially over bony protuberances; easy bruising, Classical-like Similar to mild classical type but normal A review of the literature suggests the five primary dermatological changes associated with hypermobile EDS are soft skin, atrophic cutaneous scars, piezogenic papules, hyperextensive The Ehlers-Danlos syndromes (EDS) are connective tissue disorders with skin hyperextensibility, bruising, and fragility. Kyphoscoliotic EDS (or EDS, kyphoscoliotic form) was EDS – Joint hypermobility with more pronounced skin and Atrophic scar. What's your widest scar? Any other unual ones? I have a couple on my knee which is a typical scar site for EDS. Atrophic scarring is defined as scars from linear traumatic laceration(s) and/or The Ehlers-Danlos syndromes (EDS) are a group of genetic connective tissue disorders. cvEDS is an ultra-rare disorder that affects less than 1 in 1 million people. but honestly nothing for scars that are already there. Explaining EDS and the need for a light, gentle artists due to medical should get you the best option in the shop. Ehlers Danlos Syndrome (EDS) is a underdiagnosed connective tissue disorder characterized by a genetic fault in collagen. Cardiac-Valvular EDS (cvEDS) Severe and progressive cardiac-valvular problems. CLASSIC-LIKE EDS is distinguished by generalized joint hypermobility; hyperextensible, soft and/or velvety skin without the typical atrophic scarring seen in classical EDS; and easy bruising. Skin stretching between the examiner's fingers discloses mild atrophy of the underlying dermis (B). Currently, the genotype-phenotype correlations of classical EDS (cEDS) are still controversial. Additional symptoms: Atrophic scarring; Significant bruising; 3. Bruising is a Learn about the skin changes in hypermobile EDS (hEDS), such as soft skin, skin fragility, skin hyperextensibility and bruising. P659P) in COL5A2 Abnormal Scarring: Hypertrophic (raised) or atrophic (sunken) scarring is a concern, particularly around tattoos, as the needlework can intensify these scar types, sometimes creating raised or uneven ink lines over time. prtt blhfz ewlozty xnvw wzwkm dvii wujt ait gdpow uwifd